Multiphysics modeling towards a digital twin platform for drug-loaded polyester-based implants

Introduction: The experimental design of drug-loaded long-acting implants to achieve a target pharmacokinetic release profile is timely and costly due to the lack of a theoretical understanding of the underlying physio-chemical mechanisms. In efforts to address these challenges, we propose a multiphysics model that mimics the dynamics of a polyester-based implant loaded with an active pharmaceutical ingredient (API) in an aqueous medium, thereby paving the way for the substantial reduction of design loops for a desirable release profile.