Understanding the inflammatory targeting of Lipid nanoparticles to deliver therapeutic RNAs

Chronic inflammatory pathologies are an unmet clinical need because of limited treatment options. RNA therapeutics represent a new frontier to unlock novel therapies [1]. In my work, I elucidated the effect of lipid nanoparticles (LNPs) composition in determining their tropism to the inflamed colon, resulting in a LNPs with improved merapeutic efficacy in murine colitis models [2]. Herein, I test their application in other inflammatory settings and investigate mechanism behind their biological targeting, a knowledge that could better inform future LNPs design ifor many applications.