Tech Session I: Nanomedicine and Nanoscale Delivery (Focus: Immuno)
Triazine lipids as a platform for subunit vaccine development
Tuesday, July 15, 2025
11:16 AM – 11:27 AM EDT
Introduction: Cationic lipids are versatile carriers for vaccine development. We have synthesized a class of triazine lipids for vaccine delivery with evidence of robust and balanced immunity. Our current lead lipid candidate induced and antigen-specific immunity 1500-fold greater than the control and 300-fold greater than a commercially available cationic lipid (DOTAP) using a model protein in the absence of additional adjuvants. Encouraged by these data, we sought to expand these studies by investigating the formulation characteristics and their utility as a subunit vaccine platform using ovalbumin (OVA).
Learning Objectives:
At the completion of this activity, participants will know
Understand the potential utility of triazine lipids as a platform for subunit vaccination.
Assess the advantages of triazine lipids vs. DOTAP for formulation stability and immunogenicity.
