Tech Session I: Nanomedicine and Nanoscale Delivery (Focus: Gene)
Hybrid LNP prime dendritic cells for nucleotide delivery
Tuesday, July 15, 2025
11:05 AM – 11:16 AM EDT
Introduction: Efficient activation of professional antigen-presenting cells—such as dendritic cells (DC)—in tumors and lymph nodes is critical for the design of next-generation cancer vaccines and may be able to provide anti-tumor effects by itself through immune stimulation. The challenge is to stimulate these cells without causing excessive toxicity. We hypothesized that a multi-pronged combinatorial approach to DC stimulation would allow dose reductions of innate immune receptor-stimulating agonists while enhancing drug efficacy.
Learning Objectives:
At the completion of this activity, participants will know
Design a novel hybrid nanoparticle that utilizes an approach for dual stimulation of dendritic cells
Visualize the critical role of dendritic cells in the immune system’s response to tumors.
Learn the use of advanced imaging techniques for the development of novel drug-delivery systems
