Optimizing Leuprorelin-Permeability Enhancer Complexes for Oral Release
Tuesday, July 15, 2025
3:38 PM – 3:49 PM EDT
Introduction: Leuprorelin is a peptide analog of gonadotropin-releasing hormone, used in clinical applications including treating prostate cancer, endometriosis, uterine fibroids and precocious puberty. It is currently administered by injection to bypass metabolic degradation and poor membrane permeability. An encapsulated formulation for oral colonic delivery was developed using permeability enhancers complexed with leuprorelin to protect it from enzymatic or physical degradation and ensure co-delivery to the intestinal membrane. This formulation aims to improve patient experience, compliance, and outcome.
Learning Objectives:
At the completion of this activity, participants will know
Use NMR spectroscopy to screen for peptide drug-permeability enhancer complexes.
Evaluate if permeability enhancer-peptide complexes confer metabolic protection in oral formulations
Incorporate multifactorial approaches into oral drug delivery systems.
