Fabrication of 3D-printed chewable tablets using hot melt extrusion coupled with direct extrusion

Introduction: Chewable tablets are oral dosage forms intended to be chewed and then swallowed by the patient [1]. This dosage form gained attention due to its ease of administration, making it suitable for pediatric patients [2]. Lately, 3D printing has been investigated as an innovative technology for the production of personalized medicines [3]. In this study, we described the fabrication of chewable tablets using hot melt extrusion and direct extrusion. This approach is advantageous as it avoids the printability issues of filaments, increases the bioavailability of compounds, and allows taste masking.