Formulating Biologics for Buccal Delivery: An Investigation of Feasibility and Stability

Introduction: Biologics are popular for their specificity and ability to address unmet clinical needs¹. However, their large structures degrade easily under heat or mechanical stress, forcing invasive administration that burdens patients, requires trained staff, and complicates cold-chain logistics²,³. This study tackled two challenges: first, using a novel isothermal dry particle coater (iDPC) to produce microparticulate systems that coated ovalbumin (OVA) on carrier polymers; second, demonstrating that buccal delivery is a viable non-invasive route for biologics.

Afzal Mohammed – Professor of Pharmaceutics, Aston University