Virus-inspired self-assembled vaccine to elicit B and T cell immunity against cancer

Introduction: Vaccines have emerged as a highly promising approach for cancer treatment over the past decade. While T cell-based immunity has traditionally been the primary focus of cancer immunotherapy, the role of B cells and humoral immunity is increasingly being recognized as essential. B cells not only produce antibodies but also serve as antigen-presenting cells and play a crucial role in intratumoral tertiary lymphoid structures. Despite their significant potential in cancer immunity, B cells remain largely underutilized in cancer treatment strategies.

Dirk Baumjohann – Prof. Dr., Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, Bonn University Clinic; Maximilian Moll – PhD student, Bonn University Clinic; Bi Wang – Postdoc, Department of Polymer Therapeutics, RWTH Aachen University