Tech Session II: Nanomedicine and Nanoscale Delivery (Focus: Imaging)
A DNA-Guided Lipid Nanoparticle Platform for Targeted Drug Delivery Beyond the Liver
Tuesday, July 15, 2025
3:38 PM - 3:49 PM EDT
Location: 121 B/C
Introduction: To address the problem of hepatic accumulation upon systemic administration, there is a need for liver-detargeting formulations that offer tunability for active targeting. To meet this need, we present ‘LipiGo,’ a nanocarrier platform combining LNPs with DNA nanotechnology. By incorporating oligonucleotides into the LNP structure, LipiGo enables tunable size, charge, and biodistribution profiles. Additionally, through complementary DNA hybridization, it facilitates the precise attachment of targeting ligands, making it a versatile and powerful system for targeted delivery.
Learning Objectives:
At the completion of this activity, participants will know
Understand how to integrate benefits of LNPs and DNA nanotech in particles to enhance functionality.
Learn how ssDNA incorporation in LNPs alters physicochemical properties, affecting biodistribution.
Explore how LipiGo enables modular nanoparticle surface functionalization for tailored applications.
