Tech Session III: Delivery to the Nervous System I
Breaking Barriers: Gold Nanoparticle-Based Strategies for Delivering Biologics to the Brain
Wednesday, July 16, 2025
10:29 AM – 10:54 AM EDT
Introduction: Biologics such as therapeutic antibodies have revolutionized medicine, providing effective treatments for diseases ranging from cancer to autoimmune diseases. However, their application in treating brain diseases has been limited due to the impermeability of the blood-brain barrier (BBB) (1). We have developed insulin-coated nanoparticles with high brain penetration (2-5). Here, we demonstrate a novel insulin-gold nanoparticle (GNP) platform designed to efficiently deliver multiple therapeutic agents, including antibodies and small molecules, to the brain, for disease diagnosis and therapy.
Learning Objectives:
At the completion of this activity, participants will know
Define GNP binding of molecules in various orientations, amounts and combinations for brain delivery
Describe GNPs as theranostic agents for real-time therapy tracking for patient stratification
Define insulin's role as a ‘Trojan horse’ for targeted nanoparticle transport across the BBB.
