Thermo-reactive In-situ forming Liposome Depot (TILD): From computational design to in-vivo efficacy

Introduction: Frequent drug administrations burden patients and caregivers, leading to poor adherence and suboptimal outcomes, particularly in geriatric, incapacitated, and veterinary populations.[1-2] In veterinary medicine, effective pain management often requires complex treatment schemes, causing distress for animals and strain for pet owners.[1] To address these challenges, we developed TILD, a temperature-triggered liposomal delivery system forming depots in the subcutaneous space. TILD enables sustained drug release over several days and significantly enhancing patient comfort and treatment efficacy.