The lipid nanoparticle shape and morphology affect the efficiency and duration of mRNA transfection

Lipid nanoparticles (LNP) are promising nucleic acid carriers with potential for treating various diseases (1). However, their rapid clearance, high liver accumulation, and poor transfection efficacy often hinder their effectiveness and applicability. It has been hypothesized that LNP morphology can be optimized to improve transfection efficiency, reduce liver uptake, and enhance circulation half-life (2,3). This study aims to systematically investigate how the LNP shape impacts mRNA transfection efficacy, towards a more rational design of LNP-based drug products.