Tech Session III: Nanomedicine and Nanoscale Delivery (Nano)
Lysine-acetylated human serum albumin: enhanced uptake by cancer stem cells and application
Wednesday, July 16, 2025
10:54 AM – 11:05 AM EDT
Introduction: Cancer stem cells (CSCs) play a key role in tumour initiation, recurrence, and metastasis. CD44 receptors, which are important for cell migration, are a key biomarker for CSCs. In this study, we found that lysine-acetylated human serum albumin (Ac-HSA) is rapidly taken up by CD44+ cancer cells and CSCs. It is known that the acetyl groups on hyaluronic acid (HA, CD44 ligand) bind to CD44 by fitting into its hydrophobic pockets [1]. Similarly, the acetyl groups on Ac-HSA may interact with CD44. This finding led to the development of an Ac-HSA nanocarrier for cancer chemotherapy.
Learning Objectives:
At the completion of this activity, participants will know
know that lysine-acetylation can alter the function of albumin, such as binding with CD44.
get a strategy to increase drug loading capacity of albumin nanoparticles.
conduct systematic in vivo evaluations in comparison with Abraxane.
