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Oral Delivery

Tech Session IV: Oral Delivery II

Tips and tricks for increasing oral drug absorption from nanoemulsions

Wednesday, July 16, 2025
3:49 PM – 4:00 PM EDT
Introduction:

Oral lipid-based drug delivery systems, especially self-nanoemulsifying drug delivery systems (SNEDDS) are able to increase absorption of poorly soluble drugs. SNEDDS are isotropic systems based on lipids and surfactants and form nanoemulsion droplets upon dispersion in aqueous media. For many BCS Class 2 or 4 drugs, however, the solubility in SNEDDS is low, thus reducing the potential of using SNEDDS, due to the large amount of lipid that has to administered with the drug dose. The aim was to assess the effect of increasing the apparent solubility of drugs in SNEDDS by different means.

Learning Objectives:

At the completion of this activity, participants will know
  • Upon completion the participant willl understadn what a superSNEDDS is?
  • The participant will be able to descibe how in vitro lipolysis works.
  • Upon completion the participant will have learned difference ways to increase drug load in SNEDDS