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Imaging in Drug Delivery

Tech Session V: Imaging in Drug Delivery

Multimodal Immunoimaging of CCR2-Driven Inflammation in Metabolically Stressed Myocardial Infarction

Thursday, July 17, 2025
10:29 AM – 10:54 AM EDT
Introduction:

Following myocardial infarction (MI), myeloid cell recruitment drives inflammation and remodeling. Obese patients with metabolic dysfunction are at increased risk of adverse cardiac outcomes1, yet early biomarkers to detect and predict immune activation are lacking. Here, we investigated the utility of CLIO-AF647 nanoparticles for noninvasive imaging of CCR2-dependent myeloid cell infiltration and hematopoietic activation in metabolically stressed mice after MI.

Learning Objectives:

At the completion of this activity, participants will know
  • Describe how cross-modal imaging detects myeloid-driven inflammation after myocardial infarction.
  • Explain the role of CCR2 signaling in hematopoietic activation and post-MI cardiac remodeling.
  • Evaluate the utility of iron nanoparticle imaging for prognosis in metabolically stressed infarcts.