Next generation 3D printed intravaginal rings for prevention of HIV and unintended pregnancy

Introduction: Multipurpose prevention technologies (MPTs) are important to protect women from unintended pregnancy and sexually transmitted infections. 3D printed intravaginal rings (IVRs) represent an attractive delivery platform that can provide superior control of drug release and product user characteristics. To optimize delivery of Islatravir (ISL) and hormone combination (etonogestrel, ENG; ethinyl estradiol, EE) in our MPT IVR, we evaluated in vitro release and in vivo pharmacokinetics (PK) in pigtailed macaques. We further investigated the efficacy of ISL IVR against simian HIV (SHIV) in macaques.

Mackenzie Cottrell – Research Associate Professor, University of North Carolina at Chapel Hill; Jasmine King – Research Assistant Professor, University of North Carolina at Chapel Hill; Amanda Schauer – Bioanalytical Chemist, University of North Carolina at Chapel Hill; Craig Sykes – Bioanalytical Assay Development Scientist, University of North Carolina at Chapel Hill; Isabella Young – Graduate Student, University of North Carolina at Chapel Hill