Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Nano)
Development of liposomes containing indacaterol maleate and ciclesonide for pulmonary delivery
Thursday, July 17, 2025
11:27 AM – 11:38 AM EDT
Introduction: This study aims to develop an innovative liposomal formulation loaded with ciclesonide (CIC) and indacaterol maleate (IND) for pulmonary administration. The goal is to enhance their mucopenetration, prevent degradation by macrophages, and improve uptake by epithelial cells. We first evaluated the impact of various PEGylated lipids (DSPE-PEG, DPPE-PEG, DMPE-PEG, DSG-PEG, DMG-PEG, and C8-Ceramide-PEG) on different properties of liposomes.
Learning Objectives:
At the completion of this activity, participants will know
Improve liposomes mucopenetration by using high concentrations of PEGylated lipids
Explain the impact of PEGylated lipids on the encapsulation of ciclesonide and indacaterol maleate
Explain the toxicity of different PEGylated lipids on macrophages
