Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Oral)
Transforming Healthcare: Treatment of Inflammatory Bowel Disease with Biocatalytic Nanobots
Thursday, July 17, 2025
11:38 AM – 11:49 AM EDT
Introduction: Inflammatory bowel disease (IBD) (Crohn’s disease and ulcerative colitis) affects over 7 million individuals globally, posing significant healthcare and economic challenges (1). The inflamed gut characterized by excessive ROS exacerbates mucosal damage (2). To address this, a modular polymeric nanobot (NB) system with distinct functionalities is being developed. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, forming the foundation for modules that enhance stability, navigation & targeted delivery in the gastrointestinal (GI) tract.
Learning Objectives:
At the completion of this activity, participants will know
Describe the design and function of the biocatalytic polymeric nanobot core for IBD management.
Analyze NB core functionalities, focusing on catalase activity & PEITC in reducing oxidative stress.
Assess the modular approach that underpins next-generation gastrointestinal nanobot systems.
