3D Printed Effervescent Foam-Releasing Capsule for Colonic Drug Delivery
Thursday, July 17, 2025
5:46 PM – 5:57 PM EDT
Introduction: Inflammatory bowel disease (IBD) is caused by chronic enteritis, making it difficult for drugs to reach the lesion, and the colon only has about 13 mL of body fluid to limit dissolution and absorption (1). Foam preparations can improve mucosal drug delivery, but rectal sprays are uncomfortable and only act on the distal colon. Therefore, this study used 3D printing to prepare a double-lumen capsule: one lumen contains a foaming agent, and the other lumen contains a foaming mixture and 5-ASA (2). It can foam in situ at the distal small intestine or proximal colon.
Learning Objectives:
At the completion of this activity, participants will know
Identify the design considerations for 3D printed foam-based drug delivery systems.
Evaluate what factors influence mechanical stability, dissolution profiles, and foam generation.
Optimize foam stability, drug-loading capacities, and patient acceptability for colonic delivery.
