Tech Session VI: Nanomedicine and Nanoscale Delivery (Focus: Gene)
Efficient Cartilage-Targeted Gene Editing via Lipid Nanoparticles for Osteoarthritis Treatment
Thursday, July 17, 2025
5:35 PM – 5:46 PM EDT
Introduction: Arthritis affects millions worldwide, with limited treatment options—only a few disease-modifying drugs for rheumatoid arthritis and none for osteoarthritis (1). Improved understanding of joint disease mechanisms has highlighted the potential of gene therapy (2-4), including replacement therapy and gene editing, as novel therapeutic strategies. While lipid nanoparticles are widely used as gene-delivery vehicles in clinical applications, the lack of tailored LNPs for efficient and precise delivery to joint tissues highlights the need for targeted therapies with reduced off-target effects.
Learning Objectives:
At the completion of this activity, participants will know
Understand the critical structural features of ionizable lipids for joint-specific gene delivery.
Investigate chondrocyte-targeting strategies for advancing joint disease therapy.
Validate the therapeutic efficacy of MMP-13 targeting for osteoarthritis treatment.
