Enhancing transmucosal uptake of GLP-1RA: Ionic lipidation and Self-Nanoemulsifying Delivery system
Thursday, July 17, 2025
5:35 PM – 5:46 PM EDT
Introduction: GLP-1 receptor analogues, are established in treating Type 2 diabetes and obesity. However, these agents face challenges while crossing epithelial membranes. Strategies including nanomaterials and use of intestinal permeation enhancers can improve fluxes across intestinal mucosae, but even then, oral bioavailability is rarely above 1% in humans (1). To address this, researchers are trying to increase the bioavailability by increasing the lipophilicity of GLP-1-RA (2). Our aim was to improve lipophilicity of GLP-1-RA and incorporate into a lipid-based self-emulsifying delivery system (3).
Learning Objectives:
At the completion of this activity, participants will know
1. Can SNEDDS with HIP-GLP-1-RA payload be achieved through screening different oils and surfactants
2. Can HIPs loaded in SNEDDS demonstrate GLP-1-RA fluxes across Caco-2 monolayers on filters?
