Nanoparticle Functionalization to Target the Circadian Clock in Alzheimer’s Disease

Introduction: Disruptions in the central circadian clock (CC) have been shown to accelerate Alzheimer’s disease pathogenesis [1,2]. While CC-targeting molecules have shown efficacy in preclinical models, their clinical success is limited by poor brain penetration due to the blood-brain barrier (BBB) and dose timing [1,3]. Nanoparticles (NPs) offer a potential solution by tunable drug release and by improving brain permeability through passive permeation and active active transport mechanisms when functionalized with brain targeting moieties.

Andrés Crespo – Postdoctoral researcher, Nanobioengineering group, IBEC; Sujey Palma-Florez – PhD student, Nanobioengineering group, IBEC; Anna Lagunas – Senior Researcher, IBEC, CIBER-BNN; Mònica Mir – Senior researcher, IBEC, CIBER-BNN, Department of Electronics and Biomedical Engineering; Paolo Blasi – Associate Professor, FaBiT, Università di Bologna; Valle Palomo – Assistant Research Professor, IMDEA Nanociencia, CIBER-NED, CNB-CSIC