Tech Session VII: Delivery to the Nervous System II
Engineering of mitochondria-enriched brain endothelial cell-derived extracellular vesicles
Friday, July 18, 2025
9:49 AM – 10:00 AM EDT
Introduction: We have previously demonstrated that microvesicles (MVs), a subset of large extracellular vesicles (EVs) contain mitochondria. MVs transfer their mitochondria into recipient brain endothelial cells (BEC) and increase recipient cell bioenergetics. Resveratrol (RES) increases mitochondrial biogenesis by activating peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α). We hypothesize that the quality and quantity of mitochondria packaged into MVs can be increased by activating PGC-1α in the donor BECs (Figure 1) and further increase the effects of mitochondrial transfer.
Learning Objectives:
At the completion of this activity, participants will know
To demonstrate that resveratrol can improve the quality and quantity of mitochondria
Increasing bioenergetics of brain endothelial cells
