Reduced griseofulvin permeation across a hollow fiber membrane due to drug micellization

Introduction: Interestingly, drug incorporation into micelles is a proposed mechanism for both positive food effect (i.e. increased drug absorption with food) and negative food effect (i.e. decreased drug absorption with food). A hollow fiber membrane (HFM) was previously characterized as a potential permeation component of a dissolution/permeation system (1-4). The objective was to assess the impact of drug micellization into various pharmaceutical surfactants on drug permeation across an HFM (5). A second objective was to identify a preferred permeation model to explain the negative surfactant effect.