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Final Program


CRS Abstract Guide

Skin and Mucosal Delivery

Tech Session V: Skin and Mucosal Delivery III

Pharmacokinetics and Skin Permeation of Psychedelic Drugs Delivered by Hydrogel-Forming Microneedles

Thursday, July 17, 2025
10:54 AM - 11:05 AM EDT
Location: 119 B
Introduction: Psychedelic drugs (PSD) greatly impacted mental health research in the 1960s but were later prohibited due to side effects from high doses [1]. Recently, interest in their therapeutic potential has resurged [2]. Transdermal drug delivery offers advantages over oral administration, including bypassing first-pass metabolism, protecting from gastrointestinal degradation, and enabling controlled, sustained release [3]. This study investigates hydrogel-forming microarray patches (HF-MAPs) for transdermal delivery of microdoses of the PSD mescaline (MES), N,N-dimethyltryptamine DMT, and 5-MeO-DMT.

Learning Objectives:

At the completion of this activity, participants will know
  • Assess pharmacokinetics and skin permeation of PSD via HF-MAPs vs IM delivery.
  • Evaluate how glycerol or PEG400 impacts HF-MAP transdermal delivery of PSD.
  • Explore HF-MAPs potential for sustained release and enhanced bioavailability in microdosing
Marco T.A. Abbate – PhD Student, School of Pharmacy, Queen’s University Belfast, UK; Chunyang Zhang – Postdoctoral Research Fellow, School of Pharmacy, Queens Uiversity Belfast; Aaron R.J. Hutton – Postdoctoral Research Fellow, School of Pharmacy, Queens Uiversity Belfast; Yara A. Naser – Postdoctoral Research Fellow, School of Pharmacy, Queens Uiversity Belfast; Yaocun Li – Postdoctoral Research Fellow, School of Pharmacy, Queens Uiversity Belfast; Alejandro J. Paredes – Senior Lecturer, School of Pharmacy, Queens Uiversity Belfast; Ryan F. Donnelly – Professor, School of Pharmacy, Queens Uiversity Belfast