Nanoparticle-Enabled Endogenous Targeted Delivery of Nucleic Acid Therapies

The development of safe and effective drug delivery systems remains a cornerstone of precision medicine. This presentation will discuss the emerging field of endogenous nanoparticle-enabled targeted delivery, focusing on how intrinsic systems such as protein corona, cell-based delivery, and extracellular vesicles - can be engineered for site-specific therapeutic transport. By leveraging the inherent biocompatibility, immune evasion properties, and tissue-targeting capabilities of these biomimetic systems, we and others are overcoming key barriers in drug delivery, including off-target toxicity and limited bioavailability. I will specifically discuss the design principles, functionalization strategies, and translational potential of these platforms across a range of applications, from cancer to inflammatory and genetic diseases.