(156) A new technology for photo-controlled release of bioactive molecules in the brain.
Introduction: Neurological diseases are major causes of disability and mortality. Oral treatments are limited by the blood-brain barrier and side effects (1). Polymersomes offer a promising drug delivery system due to their stability and versatility, yet they lack precise control over release timing (2). Meanwhile, optogenetics enables brain circuit monitoring but not localized drug release. Our neurotechnology combines drug efficiency and optical stimulation to control the release of molecules into specific brain targets, offering new therapeutic strategies for localized brain diseases e.g. glioblastoma.
Learning Objectives:
Identify the main challenges of controlled release in neuroscience.
Recognize the main steps for the design of biocompatible polymersomes.
Estimate the efficiency of polymersomes photostimulation with electrophysiology.
