(244) Particle shape modulates macrophage phenotype: Insights for cell-mediated drug delivery systems

Introduction: Adoptive cell transfers (ACTs) constitute an emerging platform for improving the systemic delivery of nano- and microparticle systems. Immune cells, like macrophages (Mφ), have the capacity to enhance particle delivery in vivo through chemotaxis, and once delivered, the cells can participate in the intended therapeutic effect as well. However, little is known about how macrophage transport and function may change in response to carrying particles of different shapes, and whether these changes can be leveraged to improve the performance of adoptive cell transfers.

Nicole Day – PhD, University of Colorado Boulder; Iain Konigsberg – Research Instructor, University of Colorado Anschutz Medical Campus; Evan Thoresen – Undergraduate Researcher, University of Colorado Boulder; Abigail Harrell – Graduate Student, University of Colorado Boulder; Celeste Busch – Undergraduate Researcher, University of Colorado Boulder; Elizabeth Davidson – Senior Professional Research Assistant, University of Colorado Anschutz Medical Campus; Ivana Yang – Professor, University of Colorado Anschutz Medical Campus; Wyatt Shields – Assistant Professor, University of Colorado Boulder