(244) Particle shape modulates macrophage phenotype: Insights for cell-mediated drug delivery systems
Introduction: Adoptive cell transfers (ACTs) constitute an emerging platform for improving the systemic delivery of nano- and microparticle systems. Immune cells, like macrophages (Mφ), have the capacity to enhance particle delivery in vivo through chemotaxis, and once delivered, the cells can participate in the intended therapeutic effect as well. However, little is known about how macrophage transport and function may change in response to carrying particles of different shapes, and whether these changes can be leveraged to improve the performance of adoptive cell transfers.
Learning Objectives:
Explain current opportunities in particle-based ACTs
Describe the effect of particle shape on macrophage transport and function
