(297) Urease-powered nanomotors for enhancing bladder cancer chemotherapy
Introduction: Bladder cancer is one of the most common and most expensive cancer types worldwide due to high recurrency rates leading to the need of improved therapies. The ability of nanomotors to actively move in complex microenvironments has revolutionized the field of nanomedicine in the past years [1,2]. Herein, we present urease-powered nanomotors based on mesoporous silica nanoparticles which can actively move within the bladder [3,4]. By loading the nanomotors with a clinical relevant drug like Mitomycin C we aim to improve the drugs’ therapeutic efficiency in the treatment of bladder cancer.
Learning Objectives:
Define the word "nanomotor" and describe their advantages over conventional drug delivery systems
List drug-loading approaches to obtain functional nanomotors
Describe techniques to determine the therapeutic potential of actively moving urease-nanomotors
Maria Crespo, mcrespo@ibecbarcelona.eu – Postdoctoral researcher, IBEC; Valerio Di Carlo, vdicarlo@ibecbarcelona.eu – Senior Technician, IBEC Barcelona; David Esporrín Ubieto, desporrin@ibecbarcelona.eu – Postdoctoral researcher, IBEC Barcelona; Acsah Konuparamban, akonuparamban@cicbiomagune.es – PhD student, CIC biomaGUNE; Jordi Llop, jllop@cicbiomagune.es – Group Leader, CIC biomaGUNE; Inés Macias Tarrio, imacias@ibecbarcelona.eu – PhD student, IBEC Barcelona; Samuel Sánchez Ordóñez, ssanchez@ibecbarcelona.eu – Group Leader / ICREA Research Professor, IBEC Barcelona
