(354) Microneedle enabled dual drug delivery system for vaginal infections using magnetic hyperthermia
Introduction: About 75% of women are susceptible to vulvovaginal candidiasis (VVC), and majority show a recurrent form of the infection. Current vaginal therapies not only lack sufficient mucus penetration and drug retention, but also show increasing drug resistance. Addressing these barriers, clotrimazole loaded lipid based nanocarriers have been incorporated into microneedles (MNs) (1). Here, we explore the dual action of drug-releasing microneedles with magnetic hyperthermia to combat VCC. The combined action can have a synergistic effect on the eradication of C. albicans biofilms (2).
Learning Objectives:
Develop nanoparticle loaded microneedles for local vaginal drug delivery of antimicrobials.
Prove the use of magnetic hyperthermia as a synergistic tool to eradicate fungal biofilm.
Demonstrate the use of relevant in vitro and ex vivo models to evaluate the drug delivery systems.
