(434) Mucoadhesive Polymer-Drug Conjugate and Nanoparticle for Anterior Ophthalmic Drug Delivery
Introduction: Anterior segment drug delivery via eye drop is the gold standard of therapeutic delivery, though 95% of the applied drop is cleared within 5 minutes. Eye drops therefore require frequent, high concentration administrations, causing off-target effects and toxicity, while the frequent dosing regime lowers patient compliance. To sustain the drug on the anterior segment, a mucoadhesive polymer was developed. This polymer was conjugated to model therapeutics or copolymerized with a hydrophobic component to form a nanoparticle (NP) capable of releasing hydrophobic drugs over a sustained period.
Learning Objectives:
Create a polymeric system to deliver various drugs to anterior tissues over a prolonged period
Verify the system demonstrates compatibility with relevant tissues and cell lines
Ensure the drugs conjugated or added into the system remain active
