(501) Amplifying Dual-Drug Microspheres Capacity via Formulation Optimization and Computational Simulation
Introduction: Polymeric microspheres can tailor the pharmacokinetic features of encapsulated drugs, thereby prolonging synergistic therapeutic effects with minimal toxicity (1,2). Rational design of dual-drug microspheres enhances the retention of drug molecules during emulsion droplet solidification, overcoming the drug-carrier compatibility limitation and increasing the drug payload per unit of polymer (3,4). Given the limited injection volume for localized administration, dual-drug microspheres with higher capacity enable enhanced drug delivery to confined sites in a single injection (5).
Learning Objectives:
Understand the screening process of promising dual-drug used for higher capacity microspheres.
Explain the mechanism of the enhanced capacity in dual-drug microspheres from microscopic insights.
Evaluate the potential of candidate dual-drug microspheres used for localized administration.
