(508) Impact of Gelling Agent on Physicochemical and Q3 Properties of Clobetasol Propionate Gels
Introduction: Gels are one of the common pharmaceutical dosage forms for topical delivery of drugs. Variations in the formulation composition and/or manufacturing process might affect the physicochemical and structural (Q3) characteristics and, consequently, the effectiveness of topical treatment. Hence, the aim of this work was to study the effect of different inactive ingredient concentrations, sources, and grades on the physiochemical and structural (Q3) properties of 0.05% clobetasol propionate topical gels.
Learning Objectives:
Assess how gelling agent type, grade, and concentration affect topical gel properties.
Compare the effects of pharmaceutical- versus cosmetic-grade HPMC on clobetasol propionate gels.
Understand formulation strategies to optimize topical gel quality and efficacy.
