(181) Multi-engineered selenium nanoparticles: a smart shuttle for gene therapy of BRAF-mutated melanoma

Introduction: RNA interference (RNAi) via small interfering RNAs (siRNAs) is a potent therapeutic tool.1 It shows particular advantages in diseases resistant to classic treatments, by specifically silencing a target gene. Moreover, nanoparticles (NPs) are effective for gene delivery2,3, because they enhance the stability and allow controlled release of the therapeutics. Among them, selenium nanoparticles (SeNPs) have been recently used for tumor gene- and immune-therapy.4,5 Here, multi-engineered SeNPs are used to deliver an anti-BRAF siRNA (siBRAF), in mutated melanoma cells to achieve antitumor effects.