(297) Urease-powered nanomotors for enhancing bladder cancer chemotherapy

Introduction: Bladder cancer is one of the most common and most expensive cancer types worldwide due to high recurrency rates leading to the need of improved therapies. The ability of nanomotors to actively move in complex microenvironments has revolutionized the field of nanomedicine in the past years [1,2]. Herein, we present urease-powered nanomotors based on mesoporous silica nanoparticles which can actively move within the bladder [3,4]. By loading the nanomotors with a clinical relevant drug like Mitomycin C we aim to improve the drugs’ therapeutic efficiency in the treatment of bladder cancer.